Category: Lipids/CV Health

Monitor: 27

27 - Effects of Conjugated Linoleic Acid (CLA) on Insulin Resistance and BMI in Subjects with and without the Metabolic Syndrome: A Systematic Review and Meta-analysis

Thursday, Apr 25
1:00 PM – 1:30 PM

Objective :

CLA supplementation has been widely used by the general population as a weight reduction agent. In-vitro and animal studies have reported beneficial metabolic effects while reports in humans have been mixed, with some even reporting adverse effects. The aim of the present study is to review and synthesize the available evidence from randomized controlled trials (RCTs) of CLA on body weight (BMI) and insulin resistance (HOMA-IR).


Methods :

We conducted a systematic literature search to identify studies up to December 2017. Only RCTs with CLA t10-c12 isomer or mix 50:50 CLA t10-c12 and c9-t11 as intervention on individuals with or without components of the metabolic syndrome were selected. Individual study results were pooled to obtain weighted mean differences (WMDs) with 95% confidence intervals (CI), funnel plots assessed small study effects and subgroup analysis helped explore a priori identified sources of heterogeneity.


Results : A total of 24 RCTs met the inclusion criteria and 19 were eligible for meta-analysis of one or more outcomes of interest. For BMI, the combined result from 15 individual studies showed a reduction of 0.26 units (95%CI -0.47, -0.05) in the intervention group vs placebo (p=0.017). No statistically significant difference was observed from pooling 7 studies on HOMA-IR, a few of which rather indicated a negative effect.


Discussion : Our review demonstrates a weight-lowering influence of CLA. However, although the effect seems consistent, its magnitude does not convincingly suggest clinical relevance. In terms of insulin resistance, there does not seem to be any beneficial effect, and small studies showing adverse effect warrants further scrutiny.


Conclusion : There is no benefit using CLA for improving insuiln resistance and questionable clinical relevant benefit on body weight.

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Ricardo Correa

Endocrinology, diabetes and metabolism fellowship director
University of Arizona College of Medicine-Phoenix and Phoenix VA
Phoenix, Arizona

Ricardo Correa, M.D., Es. D., F.A.C.P., C.M.Q. is an Assistant Professor of Medicine and Program Director for the Endocrinology, Diabetes and Metabolism of the University of Arizona College of Medicine-Phoenix and the Warren Alpert Medical School of Brown University in the department of Endocrinology, Diabetes and Metabolism. He is the chair of the young physician subcommittee of the American Association of Clinical Endocrinologist (YPS-AACE). Also he is editor of Dynamed and outreach unit director of Endotext.org and Thyroid manager and editorial board of multiple endocrine and internal medicine journals.
He completed his Medical School and Education Master at University of Panama. He completed a research fellowship in Epidemiology and Tropical disease at ICGES in Panama City and his internal medicine residency at Jackson Memorial hospital-University of Miami (UM) program. In 2012, he was honored with the AOA and GoldDOC Award from the UM. Then he pursued his clinical and research fellowship in endocrinology with special focus in neuroendocrinology and adrenals at National Institute of Health.
He was trained in Evidence-based Medicine at McMaster University in Canada and in Editorial process and OJS by LATINDEX. He is co-director of the Panamanian Cochrane Center and EBM advocate.
Dr. Correa has been involved in organized medicine since medical school. He has been scientific committee chair and vice speaker for the AMA-RFS, chair of the CoA for the ACP FC, Board of Trustee of the Maryland Medical Society, National Secretary of the CoA for the NHMA, Regional Vice President of the CIR, Medical Education Officer of JDN-WMA. He has been involved with local, regional and national organization in the area of medical education, leadership and physician wellbeing including the AMA joy in medicine organization, ACGME at different level including the duty hour task force, NBME as part of the board, NBPAS and other organization.
At AACE and ACE and Endocrine Society, Dr. Correa has occupied different position from been the fellow-in-training board of director member to member and advisor of multiple committees throughout the years.
Dr. Correa has been involved in multiple academic, scientific and educational activities including article Consultant, Interpretation of the Medical Literature Project, NBME, International Committee member of the Committee on publications ethics (COPE), World Association of Medical Editors, Deputy Editor of International Archives of Medicine, Editorial board and peer reviewer of multiple journals including Annals of Public Health, PAHO journal, SGIM journal, International Journal of Endocrinology, International Journal of Diabetes, International Journal of Clinical Cases and Images, International journal of case reports, etc. Also he is consultant for Latinamerican science center including Bolivia and Panama national science department.
He is board certified in Medical Quality. He is the author of the book title “Case report: basics and publication”. His research is focus on neuroendocrinology mainly on pituitary and adrenal tumor and new genetic mutations.

Rossana Calderon

Endocrinologist and Nutrition Fellow
Columbia University, New York

Rossana is an endocrinologist that is doing a nutrition fellows at Columbia University.

Anna Sara Oberg

Professor of Public Health
Harvard School of Public Health, Massachusetts

Anna is a professor of public health at Harvard School of Public Health

Stefania Papatheodorou

Professor of Public Health
Harvard School of Public Health, Massachusetts

Stefania is a professor of Public Health at Harvard School of Public Health

Kelvin Tran