Category: Other - VITAMIN D DEFICIENCY

Monitor: 35

35 - SERUM VITAMIN D LEVELS AND RETINOPATHY AMONGST NIGERIANS WITH TYPE 2 DIABETES

Saturday, Apr 27
11:30 AM – 12:00 PM

Objective :

To assess the relationship between serum vitamin D and diabetic retinopathy in Nigerians with type 2 diabetes.


Methods :

A hospital-based, descriptive cross-sectional comparative study was carried out at tertiary hospital in Nigeria between October 2016 and March 2017. We studied 150 patients with type 2 diabetes and 150 matched controls. History obtained included biodata, duration of sun exposure, percentage body surface area exposed, use of tobacco and alcoholic beverages as well as multivitamin use. Systemic examination included a dilated fundus examination which was followed by a wide field stereoscopic retinal photography. 


Serum 25-hydroxy-vitamin D, fasting and post prandial blood glucose, glycated haemoglobin, electrolytes and liver function tests were assessed. Vitamin D deficiency was defined by serum vitamin D levels 20ng/ml.


Results :

The rate of occurrence of retinopathy was significantly higher in subjects with vitamin D deficiency than in those with normal vitamin D levels (62% vs. 17.6% p(AOR=.866 CI=0.799-0.939, p=0.001).The mean vitamin D level was significantly lower in diabetics with retinopathy compared to those without retinopathy {25.81ng/ml (12.66) vs. 40.30ng/ml (14.73); p<0.001}. Following adjustment for blood pressure control, male sex, fasting and post prandial blood glucose, glycated haemoglobin and low density lipoprotein,serum vitamin D was found to independently predict the occurrence of retinopathy(AOR=.866 CI=0.799-0.939, p=0.001).


Discussion :

Diabetic retinopathy is a major outcome of type 2 diabetes mellitus with huge impact on the quality of life, significant burden to the health sector with increased risk of blindness. From this study, themean serum vitamin D levels amongst subjects with retinopathy were lower than those without retinopathy.

Retinopathy was also observed in a statistically significantly higher proportion of subjects with vitamin D deficiency compared to those without vitamin D deficiency. This relationship between retinopathy and serum vitamin D was maintained even after adjustment for potential cofounders. Vitamin D deficiency was found to be a significant predictor of retinopathy.


Conclusion :

This study shows an inverse relationship between vitamin D levels and occurrence of retinopathy in Nigerians with type 2 diabetes.


 

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Odiase SPECIAL.. OMONUA

Physician/Endocrinologist
Abuja, Nigeria
Gwagwalada, Federal Capital Territory, Nigeria

Fellow of the National Postgraduate Medical College of Nigeria. A Physician/Endocrinologist in Abuja, Nigeria.

Felicia Anumah

Professor of Medicine/Endocrinology
University of Abuja College of Health Sciences and University of Teaching Hospital
Abuja, Federal Capital Territory, Nigeria

Fellow of National Postgraduate Medical College. Professor of Medicine and Endocrinology. Fellow American College of Endocrinology

Rifkatu SONNIE.. Reng

Senior Lecturer and Consultant Endocrinologist
College of Health Sciences, University of Abuja and University of Abuja Teaching Hospital
Abuja, Federal Capital Territory, Nigeria

Fellow of the National Postgraduate Medical College of Nigeria. A Physician/Consultant Endocrinologist. Senior Lecturer, College of Health Sciences. Fellow of American College of Endocrinology

Francis UCHENNA.. Nwako

Ophthalmologist
University of Abuja Teaching Hospital
Gwagwalada, Nigeria

Ophthalmologist in Federal Tertiary Centre with Subspecialzation training in Retinopathy and Neuro-opthalmology