Category: Diabetes/Prediabetes/Hypoglycemia

Monitor: 29

29 - SERUM OSTEOCALCIN AND METABOLIC PARAMETERS CORRELATION IN POSTMENOPAUSAL WOMEN WITH AND WITHOUT TYPE 2 DIABETES

Thursday, Apr 25
11:30 AM – 12:00 PM

Objective :

Osteocalcin is the main non-collagenous protein in bone matrix. But, when present in the blood, it represents an osteoblast-derived hormone that exerts a series of biological effects on beta-pancreatic and adipose cells, outlining a complex relationship between bone tissue and energetic metabolism, which may be affected by a series of disorders, such as the type 2 diabetes mellitus (2DM).


We evaluated the relationship between bone metabolism and metabolic parameters in postmenopausal women with and without type 2 diabetes. 


Methods :

We conducted a cross-sectional study in a Tertiary Endocrine Center, East Europe on postmenopausal women without known prior bone pathology or anti-osteoporotic drugs exposure. Evaluation included: clinical parameters: weight, height, body mass index (BMI), glycemic profile,  lipid profile, serum creatinin, and the levels of parathyroid  hormone (PTH), 25 hydroxy vitamin D (25(OH)D) and serum osteocalcin. For data analysis we used Student’s t-test and Pearson correlation (statistical significance at p <0.05).


Results :

Were enrolled 165 postmenopausal women of which 68 women (63.84±8.49 years) with 2DM and 97 without diabetes (60.85±8.81 years). In the group of patients with 2DM the levels of HDL-cholesterol (p=0.007), osteocalcin (p<0.05) and 25(OH)D (p=0.04) were lower, but with higher BMI, fasting glucose, HbA1c and triglycerides levels (p<0.05). Osteocalcin and elements of the metabolic syndrome correlated negatively with BMI (r=-0.375,p<0.05), HbA1c (r=-0.247,p=0.001), respective with triglycerides (r=-0.332,p<0.05) and positively with HDL-cholesterol level (r=0.258,p=0.001) for the whole group of patients.There was a positive correlation between osteocalcin and PTH in the whole group of patients (r=0.258,p=0.001), including the 2DM group (r=0.333,p=0.005).


Discussion : Our study indicated the presence of significant correlations between serum osteocalcin and glycemic and lipid metabolism parameters independent of the presence of type 2 diabetes mellitus.


Conclusion : Osteocalcin is more than a bone marker, being considered  a main component of the complex relatioship between bone tissue and energetic metabolism.

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Adina MARIANA. Ghemigian

Doctor
C.I. Parhon National Institute of Endocrinology, Bucuresti, Romania

.

Andra Cocolos

MD
Carol Davila University of Medecine, Bucharest

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Mara Carsote

MD
National Institute of Endocrinology C.I Parhon

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Andra Caragheorgheopol

Senior Resercher
Research Laboratory, C. I. Parhon National Institute of Endocrinology, Bucharest, Romania

NA

Constantin Dumitrache

MD
National Institute of Endocrinology C.I Parhon

.

Nicoleta Dumitru

MD
National Institute of Endocrinology C.I Parhon, Bucuresti, Romania

.

Adina MARIANA. Ghemigian

Doctor
C.I. Parhon National Institute of Endocrinology, Bucuresti, Romania

.