Category: Other - Parathyroid

Monitor: 26

26 - SERUM KLOTHO LEVELS IN POSTMENOPAUSAL PRIMARY HYPERPARATHYROIDISM PATIENTS

Thursday, Apr 25
12:30 PM – 1:00 PM

Objective : Primary hyperparathyroidism (PHPT) is a common endocrine disease characterizing higher serum calcium and parathyroid hormone (PTH) levels. Over time, PHPT can cause osteoporosis, cardiovascular disease and renal function decline. Klotho predominantly expressed in kidney and parathyroid glands and is identified as a regulator of calcium channel-dependent cell physiological process. The objective of this study is to investigate serum Klotho levels and its correlation with major indicators of PHPT in postmenopausal.


Methods :

38 postmenopausal women, 19 PHPT patients and 19 healthy controls, were recruited in this study. Blood samples were collected when subjects enrolled the study. Age and BMI of all subjects were reviewed from electrical medical records. PTH, 25-hydroxyvitamin D (25OHD), albumin, and calcium levels were determined by the biochemical laboratory. Serum Klotho levels were determined by enzyme-linked immune sorbent assay (ELISA). Mean and standard deviation were used to summarize the data. Student’s t test and Wilcoxon rank sum test were used to make comparison. Pearson correlation coefficients were used to assess relationships with Klotho and other parameters. Two-sided p values of 0.05 were selected as significance level.


Results :

There is no difference in age and BMI between postmenopausal PHPT and control groups (p>0.05). Compared to age healthy postmenopausal controls, patients with PHPT had higher PTH (112.10±37.99 vs 36.05±17.60 pg/mL, p<0.0001), higher calcium (10.99±0.65 vs 9.40±0.39 mg/dL, p<0.0001) and 35% higher serum Klotho levels (22.86±8.30 vs 16.87±7.85 ng/mL, p=0.0282). In Pearson correlation coefficients analysis, Klotho levels were negatively correlated with albumin (r=-0.532, p=0.0007) and positively correlated with calcium (r=0.327, p=0.0484). Serum Klotho and PTH were almost significantly positively correlated (r=0.302, p=0.0655) with each other.


Discussion : Our data showed in first time that serum Klotho levels are higher in postmenopausal PHPT women compared to age and BMI match-controlled subjects. It is possible that Klotho mediates PTH effects on serum albumin and calcium levels in PHPT patients. The physiological significance of higher Klotho levels in postmenopausal PHPT patients and the underline mechanism required further investigation.


Conclusion : Klotho levels are higher in postmenopausal PHPT patients. Klotho levels are negatively correlated with albumin, positively correlated with calcium, and almost significantly positively correlated with PTH levels.

Chi Su

Student
Rutgers Biomedical and Health Sciences, Rutgers University
Edison, New Jersey

Achieved M.D. degree and medical practice license in China. Now doing a master program in Rutgers, majoring Clinical and Translational Sciences.

Lingqiong Meng

student
Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University

Achieved MD degree in China, now doing a PhD program in Rutgers University

Sue A. Shapses

PROFESSOR
Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University

Professor of Nutritional Sciences, Rutgers.
Director, New Jersey Obesity Group.
Ph.D. Columbia University, 1988

Xiangbing Wang

PROFESSOR
Division of Endocrinology, Metabolism & Nutrition, Rutgers University-Robert Wood Johnson Medical School

Dr. Xiangbing Wang is an endocrinologist in New Brunswick, New Jersey and is affiliated with Robert Wood Johnson University Hospital. He has been in practice for more than 20 years.

Stanley Z. Trooskin

Chief, Professor of Surgery
Rutgers RWJMS
NEW BRUNSWICK, New Jersey