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1 - ASSESSMENT OF VON WILLEBRAND FACTOR (vWF) AND ITS CORRELATION WITH CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH AND WITHOUT TYPE 2 DIABETES

Thursday, Apr 25
11:00 AM – 11:30 AM

Objective :

Brachial-ankle pulse wave velocity (baPWV) is a method to estimate arterial stiffness, which reflects the stiffness of both the aorta and peripheral artery. Traditional risk factors like dyslipidemia, altered BMI and hypertensive are known risk enhancers for coronary artery disease. Von willebrand factor (vWF) is a large multimeric glycoprotein present in plasma and is considered as an accurate predictor of the vascular risk. We conducted a study to the role and correlation of vWF with other cardiovascular risk factors in patients with type 2 diabetes and the corelates were compared with the non-diabetic population


Methods :

Forty-six patients were matched as 1:1 studied in two groups of 23 patients each group of diabetics (DG) and another as non-diabetic patients (NDG). vWF, baPWV along with other risk factors like lipid profile, albuminuria, hypertension, BMI and HbA1c were evaluated. Unpaired t-test and Mann Whitney test were utilised for the statistical analysis.


Results :

The mean baPWV in the DG was higher (1434 cm/s) as compared to NDG (1315 cm/s). Similarly, mean vWF in DG (297 IU/dl) was higher than the NDG (202 IU/dl) group. A weak correlation of vWF was seen (r=0.29; p value 0.01) with urinary proteins in both the groups. There was no statistical correlation observed with baPWV (p=0.94) and other risk factors including HbA1c (p=0.47), BMI (p=0.57), cholesterol (p=0.08), LDL-C (p=0.47) studies in both DG and NDG


Discussion :

Our study demonstrated that vWF is a marker of endothelial dysfunction and is elevated in the patients with type 2 diabetes. There was no such remarkable correlation with  baPWV and other risk enhancers. A targeted drug design and development program to decrease the elevated vWF would be useful to mitigate the enhanced CV risk and improve cardiovascular outcomes in T2DM patients.  


 


Conclusion :

There striking correlation for the elevated vWF in T2DM and the absence of such direct correlation with  baPWV. We postulate that the estimation of vWF in T2DM should be explored in real world setting and also the results of our study can be the basis for further large scale randomised controlled trials to further explore this evidence.

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Rohit Kapoor

Director
Care Well Heart and Super Speciality Hospital

Care Well Heart and Super Speciality Hospital

Shivam Kapoor

Senior Resident
Care Well Heart and Super Speciality Hospital

Care Well Heart and Super Speciality Hospital

Rishabh Kapoor

Senior Resident
Care Well Heart and Super Speciality Hospital

Care Well Heart and Super Speciality Hospital

Vipan Talwar

Consultant Endocrinologist
Golden Hospital,Jalandhar,India

Name Dr. Vipan Talwar
MBBS ,MD,(Medicine) ,DM, (Endocrinology)
Present Position
Director & Sr. Consultant - Endocrinology and Diabetes at Golden Hospital, Jalandhar

Teaching Experience :Five Years of experience of teaching post graduate students at Safdurjung Hospital, New Delhi and PGIMER Chandigarh
Awards : *Rotary award for Excellence in field of Medicine, * J S A Award for Outstanding Services in Medical Field
Publications :Number of publications as Orignal articles, review articles, case reports in International and national indexed journals.
Areas of interest
• Diabetes,,CGMS,AGMS ,Insulin Pumps
• Obesity, Thyroid disorders,
• Growth disorders, Adrenals disorder
• Reproductive Endocrinology.