Category: Thyroid

RISK FACTORS FOR THYROID DISORDERS AMONG PATIENTS WITH HIV/AIDS IN NORTHERN NIGERIA

Monday, Apr 8
1:00 AM – 2:00 AM

Objective :

The association of HIV / AIDS and thyroid disorders have been described with several possible risk factors identified as contributory to the development of thyroid disorders in the setting of HIV / AIDS. Unfortunately, only very few studies have attempted to identify the risk factors for thyroid disorders among Nigerians living with HIV / AIDS. The objective is to determine the risk factors for thyroid disorders among HIV/AIDS patients in Kano


Methods :

The study was cross-sectional hospital-based comparative with consecutive recruitment of HIV / AIDS patients and HIV negative patients attending the Aminu Kano Teaching Hospital PEPFAR / HIV clinic and GOPD respectively over a two months period. Demographic data, relevant history of risk factors, anthropometry and blood pressure measurements, and thyroid examination were undertaken and captured in an interviewer-administered questionnaire. Laboratory data evaluated   include thyroid function tests, anti-TPO antibody, fasting plasma glucose, CD4 cell count, viral load, plasma lipids and complete blood count. Risk factors assessment was done using logistic regression model.


Results : A total of 115 HIV positive and 115 HIV negative subjects (20% males, and 80% females) in both groups were recruited and evaluated. The mean ± SD age of the subjects and controls was 38.2±9.54years and 35.9±13.57years respectively, p=0.138. The prevalence of thyroid dysfunction among patients with HIV/AIDS was 32.7% and the predominant pattern was primary hypothyroidism followed by isolated low FT3. Only history of diabetes among parents was found to be a risk factor for thyroid dysfunction among the patients with HIV/AIDS in Kano, Nigeria, odds ratio = 1184, 95% confidence interval = 34-410900, p =0.002.


Discussion :

From this study, the only risk factor for the development of thyroid dysfunction among the cases was the family history of diabetes. This is similar to a study done by Rasoolinejad et al. who found no relationship between, age, sex, weight and level of CD4 count, stage of disease and ARV used but significant association with positive family history of diabetes.


Conclusion : Screening of HIV/AIDS patients who have positive family history of diabetes mellitus is of paramount importance.

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Fakhraddeen YAHYA.. Muhammad

CONSULTANT
AMINU KANO TEACHING HOSPITAL
Kano, Nigeria

consultant physician/endocrinologist

Abubakar Usman

CONSULTANT
AMINU KANO TEACHING HOSPITAL

CONSULTANT PHYSICIAN/ENDOCRINOLOGIST

Adenike Enikuomehin

CONSULTANT
SPECIALIST HOSPITAL AKURE

CONSULTANT PHYSICIAN/ENDOCRINOLOGIST