Category: Thyroid

A RETROSPECTIVE MEDICAL RECORD REVIEW AND TELEPHONE SURVEY TO ACCESS THE ASSOCIATION BETWEEN SUGAR SUBSTITUTES AND GRAVES' DISEASE

Monday, Apr 8
1:00 AM – 2:00 AM

Objective :

Association between artificial sweetener and Hashimoto thyroiditis had been previously described by us. This study is designed to determine the association between the usages of sugar substitutes (artificial sweeteners) and Grave's disease.


Methods :

Based on the review of the electronic medical record, a total of 116 subjects, 93 female (80.18 %), and 23 male (19.82 %), were included in the study. 58 out of 116 (50%) were diagnosed with graves with an average age (average age 49.03 years), and  58 were healthy control (50%) with an average age of 42.17 years. The patients were asked to answer a specifically designed questioner for this study pertaining to the consumption of the artificial sweeteners.


Results : Based on cumulative data it was found that 18 out of 58 patients (31.03%) who were diagnosed with Graves’ disease consumed artificial sweeteners. The mean number of packs used by Graves’ disease group was 2.05 and mean duration is 2.7 years. While on the other hand 17 out of 58 healthy controls (29.31 %) document intake of artificial sweetener with mean no of packs 2.2, and duration 2.44 years.


Discussion :

Over the last few decades, an increase in consumption of sugar substitutes has been observed. Previous studies have shown an association between the use of sugar substitutes and the development of autoimmune disorders and cancers in animals. Aspartame, sucralose, and saccharin the main ingredients of artificial sweeteners are known to cause several side effects in animals. Aspartame gets metabolized to formaldehyde which has been associated with type 4 delayed hypersensitivity reactions. When sucralose fed to rats, a decrease in the size of thymus and spleen and lymphoma has been noted suggesting that it could have a negative effect on the immune system. Very few studies had been done on human subjects to see the adverse effects of artificial sweeteners in humans. Recently we reported the association between the use of artificial sweeteners and Hashimoto thyroiditis. The results of this study did not show such an association with Graves’ disease.


Conclusion :

This study did not show any association between Graves’ disease and the use of artificial sweetener. The previously reported association between Hashimoto thyroiditis and artificial sweetener suggests that Hashimoto thyroiditis and Graves’ disease are two different spectra of autoimmune thyroid disease and taking the history of consumption of artificial sweetener is important in Hashimoto but not in Graves’ disease patients.

SHORT URL FUNCTION-->

Amir Shahbaz

Research Assistant
NYC Health + Hospitals/Queens
New York, New York

I am a clinical researcher and my area of interest is to explore the autoimmune basis of endocrine disorders.

Paria Zarghamravanbakhsh

Resident Internal Medicine
NYC Health + Hospitals/Queens
New York, New York

Internal Medicine Resident at NYC Health + Hospitals/Queens.

Rupak Mahendhar

Research assistant
NYC Health + Hospitals/Queens
NewYork, New York

I am a clinical researcher and my primary field of interest is exploring the autoimmune basis of different thyroid diseases.

Amish Vyas

Research Assistant
NYC Health + Hospitals/Queens
New York, New York

Researcher at Diabetic Center of Excellence, Queens Hospital Center New York

Issac Sachmechi

Chief of the Division of Endocrinology
NYC Health + Hospitals/Queens
New York, New York

Chief of the Division of Endocrinology at Queens Hospital Center and Director of the Diabetes Center of Excellence.

Amir Shahbaz

Research Assistant
NYC Health + Hospitals/Queens
New York, New York

I am a clinical researcher. My primary area of interest are exploring autoimmune basis of endocrine disorders